Solubilization Site of Organic Perfume Molecules in Sodium Dodecyl Sulfate Micelles: New Insights from Proton NMR Studies

摘要: Abstract The site of incorporation solubilizates in sodium dodecyl sulfate (SDS) micellar systems has been investigated by proton NMR spectroscopy. solubilizate molecules chosen for the present study are phenol, 4-methylphenol, 4-allyl-2-methoxyphenol, anisole, 4-methylanisole, 4-propenylanisole, 1,8-cineole, and limonene. These possess a wide variety functional groups with different degrees hydrophilic/hydrophobic character thereby solubilized at locations. Aromatic compounds, especially those having phenolic-OH group, showed large upfield shift SDS methylene protons that closely linked to terminal groups. Additionally, case phenolic unresolved signals nine straight-chain bulk split into broad doublet uneven intensity. This splitting was found be dependent on concentration substrate. Based these observations, probable solubilization sites orientation substrate molecule within micelles discussed. Phenolic being most hydrophilic among set, reside boundary micelle–water interface thus influence resonances most. methoxy aliphatic relatively more hydrophobic nature, inside core result smaller shifts.