Metal-free oxidative functionalization of a C(sp(3))-H bond adjacent to nitrogen and intramolecular aromatic cyclization for the preparation of 6-amidophenanthridines.
作者： Hong Fang , Jincan Zhao , Shengyang Ni , Haibo Mei , Jianlin Han
关键词: Oxidative phosphorylation 、 Sequence (biology) 、 Radical cyclization 、 Hydrogen bond 、 Chemistry 、 Amide 、 Intramolecular force 、 Surface modification 、 Nitrogen 、 Medicinal chemistry 、 Organic chemistry
摘要: A metal-free cyclization reaction of 2-isocyanobiphenyls with amide derivatives by using tert-butyl peroxybenzoate (TBPB) as oxidant was developed, which provided an access to pharmacologically interesting 6-amidophenanthridine compounds. The reactions proceeded through a sequence functionalization the C(sp3)–H bond adjacent nitrogen atom and intramolecular radical aromatic good chemistry yields.
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