Pirfenidone inhibits PDGF isoforms in bleomycin hamster model of lung fibrosis at the translational level
作者： G. Gurujeyalakshmi , M. A. Hollinger , S. N. Giri
DOI: 10.1152/AJPLUNG.1999.276.2.L311
关键词: Fibrosis 、 Mesocricetus 、 Pirfenidone 、 Medicine 、 Hamster 、 Bronchoalveolar lavage 、 Platelet-derived growth factor 、 Pathology 、 Bleomycin 、 Molecular biology 、 Platelet-derived growth factor receptor
摘要: Pirfenidone (PD) is known for its antifibrotic effects in the bleomycin (BL) hamster model of lung fibrosis. We evaluated whether pretreatment of hamsters with PD could influence the effects of BL-induced overexpression of platelet-derived growth factor (PDGF)-A and PDGF-B genes and proteins in the same model of lung fibrosis. We demonstrate elevated levels of PDGF-A and PDGF-B mRNAs in bronchoalveolar lavage (BAL) cells from lungs of BL-treated compared with saline control hamsters by RT-PCR analysis. However, these levels …
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