On the biodegradability, mechanical behavior, and cytocompatibility of amorphous Mg72 Zn23 Ca5 and crystalline Mg70 Zn23 Ca5 Pd2 alloys as temporary implant materials.

摘要: The evolution of microstructure and mechanical properties almost fully amorphous Mg72Zn23Ca5 crystalline Mg70Zn23Ca5Pd2 alloys during immersion in Hank's balanced salt solution (HBSS), as well their cytocompatibility, are investigated order to assess the feasibility both materials biodegradable implants. Though sample shows lower wettability more positive corrosion potential, this degrades much faster upon incubation HBSS a consequence formation micro-galvanic couples between nobler Pd-rich dendrites surrounding phases. After 22-h immersion, concentration Mg ions medium containing is six times larger than for Mg72Zn23Ca5. Due Zn enrichment incipient porosity, improve within first stages biodegradation (i.e., hardness increases while Young's modulus decreases, thus rendering an enhanced wear resistance). Cytocompatibility studies reveal that neither nor cytotoxic, although preosteoblast cell adhesion some extent precluded, particularly onto surface Mg70Zn23Ca5Pd2, because relatively high hydrophobicity. Because outstanding time-evolution, use Pd-free alloy temporary implants such screws, stents, sutures envisioned.