Rosiglitazone increases extravasation of macromolecules and endothelial nitric oxide synthase in skeletal muscles of the fructose-fed rat model.

摘要: Abstract Reduced extravasation of macromolecules in skeletal muscle has recently been documented the fructose-fed rat model, corroborating a hypothesis that functional obliteration regional microcirculation might lead to hypertension and restrict access nutrients hormones their target cells. The goal this study was assess impact treatment with rosiglitazone on reduced vasopermeability observed previously model. Fructose-fed Sprague–Dawley rats were gavaged (10 μmol kg −1 per day; n =21) or vehicle only ( =19) for 3 consecutive weeks before assessing Evans Blue (EB) dye vivo distinct groups. Relative control group, mean arterial blood pressure Δ =−16.7%, P =−39.1%, =−32.8%, versus 46.1±1.2 pg ml , =+41.9%, =+37.8%, NOS isoform, most abundant immunoreactive levels VEGF. In conclusion, appears restore vascular dysfunction microcirculation, as evidenced by improved upregulation endothelium-NO system These effects se also result partial improvement insulin resistance phenomenon improving distribution muscle. This effect be independent circulating VEGF since changes plasma concentrations permeability factor lower rosiglitazone-treated group.