Concomitant occurrence of IgG4-related pleuritis and periaortitis: a case report with review of the literature.

摘要: IgG4-related sclerosing disease is an established entity with characteristic clinicopathological features. Some recent reports have demonstrated that this can occur in the respiratory system including pleura. Herein, we describe first documented case of concomitant occurrence pleuritis and periaortitis. A 71-year-old Japanese female a history essential thrombocythemia presented persistent cough difficulty breathing. Computed tomography thickening right parietal pleura, pericardium, periaortic tissue pleural cardiac effusions. Histopathological study surgical biopsy specimen pleura revealed marked fibrous lymphoplasmacytic infiltration. Phlebitis was noted, however, only few eosinophils had infiltrated. Immunohistochemical abundant IgG4-positive plasma cell infiltration high ratio IgG4-/IgG-positive cells (84%). Therefore, diagnosis made consideration elevated serum IgG4 level (684 mg/dL). Recently, spectrum has expanded, tissue. Although histopathological analysis pericardium not performed present case, it suspected clinically due to disease. Our analyses pericarditis reveal as dyspnea pericardial effusion seen therefore, important recognize these organs for accurate treatment.