Methods of determining patient response by measurement of her-2 expression

作者: Jeff Sperinde , Gundo Diedrich , Gordon Parry , Laurie Goodman , Michael Bates

DOI:

关键词: Patient responseInternal medicineClinical trialCancer treatmentTime to progressionMedicineTreatment regimenBiomarker (medicine)OncologySurgery

摘要: Methods are provided for determining or otherwise assessing the response of a patient to treatment, in particular, cancer treatment. The methods include analysis samples presence absence HER2 markers alone conjunction with other biomarkers, such as HER3 markers. In certain examples, probable time progression can be determined by first positive patients and then further stratifying using second biomarker (e.g, markers). addition, data used track patient's treatment regimen, expected success treating particular regiment, effects regiment categorizing order create homogenous group clinical trial.

参考文章(76)
Tracy Matray, Ahmed Chenna, Vincent Hernandez, Herbert Hooper, Sharat Singh, Methods for detecting a plurality of analytes by chromatography ,(2001)
Paul Theobald, Mengxiana Tang, Stephen Williams, Computer-implemented method for identifying peaks in electropherogram data ,(2003)
Sarah Bacus, Jason Hill, Targeted therapy marker panels ,(2005)
Sarajane Ross, Lisa Crocker, Gail Phillips, Animal model of ligand activated HER2 expressing tumors ,(2006)
Jeff Sperinde, Colombe Chappey, Weidong Huang, Michael Bates, Her2 diagnostic methods ,(2008)
Rajiv Dua, Sailaja Pidaparthi, Sharat Singh, Ali Mukherjee, Po-Ying Chan-Hui, Yining Shi, Hossein Salimi-Moosavi, Erbb heterodimers as biomarkers ,(2007)
Qifeng Xue, Ian Gibbons, Multiplexed enzymatic assays ,(2001)