Catalytic tandem C-C bond formation/cleavage of cyclopropene for allylzincation of aldehydes or aldimine using organozinc reagents.
作者： Takeo Nakano , Kohei Endo , Yutaka Ukaji
DOI: 10.1021/OL500208R
关键词: Amine gas treating 、 Medicinal chemistry 、 Chemistry 、 Catalysis 、 Reagent 、 Tandem 、 Cleavage (embryo) 、 Cyclopropene 、 Aldimine 、 Bond formation 、 Organic chemistry
摘要: The tandem allylation of aldehydes or an aldimine with allylzinc intermediates derived from organozinc reagents and cyclopropenes is described. present three-component reaction involves carbozincation cyclopropene sequential cleavage a cyclopropylzinc intermediate in situ without transition-metal catalyst. generated situ, which α,β-unsaturated acylanion equivalent, gave the corresponding homoallylic alcohols amine good yields.
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