Aralkyl ester soft drugs

摘要: The present invention describes a method for programming specific course and rate of metabolism parent drug compound that leads to an inactive or very weakly active nontoxic metabolite when the modified is administered. by forming one more predetermined chemical arrangement within structure where A--φ--(R)-X-R'; A absent tether moiety which allows metabolically stable connection be made compound; φ substituted aryl heteroaryl system already specifically added via A; R alkyl alkene containing chain either branched unbranched from 0 10 carbons also X carboxyl, sulfoxyl phosphatyl function R; and, R' alkyl, alkenyl, aralkyl group 1 carbons, other common leaving group, structural element as inherent portion compound.