The Potential Role of N6-Methyladenosine (m6A) Demethylase Fat Mass and Obesity-Associated Gene (FTO) in Human Cancers.
作者： Jin-yan Wang , Li-juan Chen , Ping Qiang
DOI: 10.2147/OTT.S283417
关键词: Cancer research 、 Stem cell 、 Metastasis 、 Single-nucleotide polymorphism 、 Protein kinase B 、 PI3K/AKT/mTOR pathway 、 Biology 、 Demethylase 、 Signal transduction 、 N6-Methyladenosine
摘要: N6-methyladenosine (m6A) demethylase fat mass and obesity-associated gene(FTO), previously recognized to be related with obesity diabetes, was gradually discovered dysregulated in multiple cancers plays an oncogenic or tumor-suppressive role. However, the specific expression pro- anti-cancer role of FTO various remained controversial. In this review, through summarizing available literature, we found that single nucleotide polymorphisms (SNPs) were closely cancer risk. Additionally, dysregulation implicated biological processes, such as cell apoptosis, proliferation, migration, invasion, metastasis, cell-cycle, differentiation, stem self-renewal so on. These modulations mostly relied on communications between signaling pathways, including PI3K/AKT, MAPK mTOR pathways. Furthermore, had great potential for clinical application by serving a prognostic biomarker.
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