Genotypic resistance in plasma and peripheral blood lymphocytes in a group of naive HIV-1 patients.

摘要: Abstract Background Since HIV infection cannot be completely eliminated due to the establishment of latently infected CD4+ T cell reservoirs, there is an urgent need for a clearer understanding comparative resistance profiles between plasma and PBMC in HIV-1 patients. Objectives To assess prevalence mutations associated with drug compare free cell-associated strains. Study design Genotypic analysis on viral DNA was performed 31 therapy naive patients chronic check reverse transcriptase (RT) protease before beginning antiretroviral therapy. Results Direct sequencing provirus disclosed key (such as G190A/S, V106A, K103N T215F) RT inhibitors more frequently (7 out 31) than RNA (2 31). In addition, major (D30N, M46I, I50V, I84V) PR region were only found PBMCs. Conclusions Despite small number patients, our results show different profile compartments may yield additional information first-line regimens. Further investigations larger series followed-up longer period time are required obtain in-depth meaning detectable and/or