Dishevelled activates Ca2+ flux, PKC, and CamKII in vertebrate embryos.
作者： Laird C. Sheldahl , Diane C. Slusarski , Petra Pandur , Jeffrey R. Miller , Michael Kühl
关键词: Dishevelled 、 Signal transduction 、 Cell biology 、 Frizzled 、 Biology 、 Protein kinase C 、 Flux (metabolism) 、 Ca2+/calmodulin-dependent protein kinase 、 Calmodulin 、 Wnt signaling pathway
摘要: Wnt ligands and Frizzled (Fz) receptors have been shown to activate multiple intracellular signaling pathways. Activation of the Wnt–β-catenin pathway has described in greatest detail, but it reported that Wnts Fzs also vertebrate planar cell polarity (PCP) Wnt–Ca2+ Although protein Dishevelled (Dsh) plays a dual role both PCP pathways, its potential involvement not investigated. Here we show Dsh deletion construct, XDshΔDIX, which is sufficient for activation pathway, three effectors pathway: Ca2+ flux, PKC, calcium/calmodulin-dependent kinase II (CamKII). Furthermore, find interfering with endogenous function reduces PKC by Xfz7 interferes normal heart development. These data suggest utilizes Dsh, thereby implicating as component all Fz
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John B Wallingford, Scott E Fraser, Richard M Harland, Convergent Extension: The Molecular Control of Polarized Cell Movement during Embryonic Development Developmental Cell. ,vol. 2, pp. 695- 706 ,(2002) , 10.1016/S1534-5807(02)00197-1
Michael Kühl, Laird C Sheldahl, Maiyon Park, Jeffrey R Miller, Randall T Moon, The Wnt/Ca2+ pathway: a new vertebrate Wnt signaling pathway takes shape. Trends in Genetics. ,vol. 16, pp. 279- 283 ,(2000) , 10.1016/S0168-9525(00)02028-X
Diane C. Slusarski, Victor G. Corces, Randall T. Moon, Interaction of Wnt and a Frizzled homologue triggers G-protein-linked phosphatidylinositol signalling Nature. ,vol. 390, pp. 410- 413 ,(1997) , 10.1038/37138
Rudolf Winklbauer, Araceli Medina, Rajeeb K. Swain, Herbert Steinbeisser, Frizzled-7 signalling controls tissue separation during Xenopus gastrulation Nature. ,vol. 413, pp. 856- 860 ,(2001) , 10.1038/35101621
Michael T. Veeman, Diane C. Slusarski, Ajamete Kaykas, Sarah Hallagan Louie, Randall T. Moon, Zebrafish Prickle, a Modulator of Noncanonical Wnt/Fz Signaling, Regulates Gastrulation Movements Current Biology. ,vol. 13, pp. 680- 685 ,(2003) , 10.1016/S0960-9822(03)00240-9
Mark Peifer, Donald G McEwen, The ballet of morphogenesis: Unveiling the hidden choreographers Cell. ,vol. 109, pp. 271- 274 ,(2002) , 10.1016/S0092-8674(02)00739-0
Thomas A. Drysdale, Kathryn F. Tonissen, Kristin D. Patterson, Michael J. Crawford, Paul A. Krieg, Cardiac Troponin I Is a Heart-Specific Marker in the Xenopus Embryo: Expression during Abnormal Heart Morphogenesis Developmental Biology. ,vol. 165, pp. 432- 441 ,(1994) , 10.1006/DBIO.1994.1265
Carl-Philipp Heisenberg, Masazumi Tada, Gerd-Jörg Rauch, Leonor Saúde, Miguel L. Concha, Robert Geisler, Derek L. Stemple, James C. Smith, Stephen W. Wilson, Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation. Nature. ,vol. 405, pp. 76- 81 ,(2000) , 10.1038/35011068
Michael Kühl, Laird C. Sheldahl, Craig C. Malbon, Randall T. Moon, Ca2+/Calmodulin-dependent Protein Kinase II Is Stimulated by Wnt and Frizzled Homologs and Promotes Ventral Cell Fates inXenopus Journal of Biological Chemistry. ,vol. 275, pp. 12701- 12711 ,(2000) , 10.1074/JBC.275.17.12701
Sun-Cheol Choi, Jin-Kwan Han, Xenopus Cdc42 regulates convergent extension movements during gastrulation through Wnt/Ca2+ signaling pathway. Developmental Biology. ,vol. 244, pp. 342- 357 ,(2002) , 10.1006/DBIO.2002.0602