A functional variant in the OAS1 gene is associated with Sjögren’s syndrome complicated with HBV infection

摘要: Hepatitis B virus (HBV) has been suspected to contribute several autoimmune diseases, including Sjogren’s syndrome (SS), although the exact mechanism is unknown. The 2′–5′ oligoadenylate synthetase (OAS1) one of most important components immune system and significant antiviral functions. We studied a polymorphism rs10774671 OAS1 gene in Han Chinese descent. minor allele G was significantly associated with decreased risk for SS, anti-SSA-positive SS complicated HBV infection, which have not seen anti-SSA-negative HBcAb-negative patients. Gene expression analysis showed that risk-conferring A correlated lower p46 increased p42, p48, p44. functional study enzymatic activities revealed p44, p48 isoforms display reduced capacity inhibit replication HepG2 cells compared normal isoform. Our data demonstrated variant, rs10774671, infection anti-SSA antibody-positive SS. SAS variant switches primary isoform three alternatives capacities replication. These indicated individuals harboring might be susceptible hepatitis development.