An extracellular matrix glues together the aerial-grown hyphae of Aspergillus fumigatus.

摘要: Summary Pulmonary infections due to Aspergillus fumigatus result from the development of a colony tightly associated hyphae in contact with air, either alveoli (invasive aspergillosis) or an existing cavity (aspergilloma). The fungal ball observed vivo resembles aerial obtained agar medium vitro more than mycelial mass liquid shaken conditions that have been classically used date study A. fumigatus physiology. For this reason, we embarked on analysis characteristics colonies grown static conditions. (i) Under conditions, growth is greater shaken, submerged (ii) surface revealed presence extracellular hydrophobic matrix acts as cohesive linkage bonding into contiguous sheath. (iii) composed galactomannan, α1,3 glucans, monosaccharides and polyols, melanin proteins including major antigens hydrophobins. (iv) were resistant polyenes shake, mycelium. This first three dimensional structure colony. Knowledge multicellular organization will impact our future understanding pathobiology mold pathogens.