作者: Taro Shuin
DOI: 10.1007/978-1-4757-2381-6_3
关键词: genomic DNA 、 Serine 、 Phosphorylation 、 Oncogene 、 Internal medicine 、 Threonine 、 Oncology 、 Transcription (biology) 、 Messenger RNA 、 Molecular biology 、 Homology (biology) 、 Biology
摘要: Activated proto-oncogenes play an important role in the development and progression of human cancers. C-myc, one these protooncogenes, was first identified through its homology to cancer inducing oncogene present avian myelocytoma virus MC29 (Duesberg et al., 1977). Molecular studies have revealed that c-myc protein is essential proteins for cellular DNA replication enhancement mRNA transcription. Both messenger RNA very short half-lives (<30 min) (Dani 1984; Rabbitts 1985; Jones Cole, 1987). C-myc phosphorylated at serine threonine, binds specific sequences genomic a manner analogous c-fos c-jun (Ariga 1989; reviewed by 1986). However, actual functions regulatory mechanisms expression not been fully clarified. Recently, Max DMax, two can form heterodimers with protein, were discovered (Makela 1992). Studies on may further clarify precise actions c-myc.