C-myc as a Tumor Marker for Primary Human Cancers

作者: Taro Shuin

DOI: 10.1007/978-1-4757-2381-6_3

关键词: genomic DNASerinePhosphorylationOncogeneInternal medicineThreonineOncologyTranscription (biology)Messenger RNAMolecular biologyHomology (biology)Biology

摘要: Activated proto-oncogenes play an important role in the development and progression of human cancers. C-myc, one these protooncogenes, was first identified through its homology to cancer inducing oncogene present avian myelocytoma virus MC29 (Duesberg et al., 1977). Molecular studies have revealed that c-myc protein is essential proteins for cellular DNA replication enhancement mRNA transcription. Both messenger RNA very short half-lives (<30 min) (Dani 1984; Rabbitts 1985; Jones Cole, 1987). C-myc phosphorylated at serine threonine, binds specific sequences genomic a manner analogous c-fos c-jun (Ariga 1989; reviewed by 1986). However, actual functions regulatory mechanisms expression not been fully clarified. Recently, Max DMax, two can form heterodimers with protein, were discovered (Makela 1992). Studies on may further clarify precise actions c-myc.

参考文章(117)
Spandidos Da, Pintzas A, Tiniakos D, Pollice L, Tiniakos G, Kakkanas A, Expression of ras and myc oncogenes in human hepatocellular carcinoma and non-neoplastic liver tissues. Anticancer Research. ,vol. 9, pp. 715- ,(1989)
M Blick, E Westin, J Gutterman, F Wong-Staal, R Gallo, K McCredie, M Keating, E Murphy, Oncogene expression in human leukemia Blood. ,vol. 64, pp. 1234- 1239 ,(1984) , 10.1182/BLOOD.V64.6.1234.1234
P.H. Rabbitts, J.V. Watson, A. Lamond, A. Forster, M.A. Stinson, G. Evan, W. Fischer, E. Atherton, R. Sheppard, T.H. Rabbitts, Metabolism of c-myc gene products: c-myc mRNA and protein expression in the cell cycle. The EMBO Journal. ,vol. 4, pp. 2009- 2015 ,(1985) , 10.1002/J.1460-2075.1985.TB03885.X
Eiichi Tahara, Wataru Yasui, Hisao Ito, Tetsuro Yamamoto, Kaoru Abe, Atsushi Ochiai, Noboru Yanaihara, Immunohistochemical detection of c-myc oncogene product in human gastric carcinomas: expression in tumor cells and stromal cells. Japanese Journal of Cancer Research. ,vol. 78, pp. 1169- 1174 ,(1987) , 10.20772/CANCERSCI1985.78.11_1169
Kumao Toyoshima, Nobuo Nomura, Hiroshi Ohami, Tasuku Shoji, Tadashi Yamamoto, Ryotaro Ishizaki, Koho Akimaru, Yoshizo Nakagami, Yasunori Hiraoika, Hideshi Kanauchi, Minami Matsui, Shigeru Sasaki, DNA amplification of the c-myc and c-erbB-1 genes in a human stomach cancer. Japanese Journal of Cancer Research. ,vol. 77, pp. 1188- 1192 ,(1986) , 10.20772/CANCERSCI1985.77.12_1188
B D Mariani, R T Schimke, Gene amplification in a single cell cycle in Chinese hamster ovary cells. Journal of Biological Chemistry. ,vol. 259, pp. 1901- 1910 ,(1984) , 10.1016/S0021-9258(17)43493-4
Patricio Gariglio, Miguel Cruz, Rodolfo Ocadiz, Ana M. Graef, Rene Sauceda, High Correlation between Molecular Alterations of the c-myc Oncogene and Carcinoma of the Uterine Cervix Cancer Research. ,vol. 47, pp. 4173- 4177 ,(1987)
Robert L. Comis, Samuel Litwin, Michael D. Erisman, Susan M. Astrin, Richard D. Keidan, Noncorrelation of the expression of the c-myc oncogene in colorectal carcinoma with recurrence of disease or patient survival Cancer Research. ,vol. 48, pp. 1350- 1355 ,(1988)
Alan J. Kinniburgh, Harvey David Preisler, Guan Wei-Dong, Seema Khan, Expression of the protooncogenes c-myc, c-fos, and c-fms in acute myelocytic leukemia at diagnosis and in remission. Cancer Research. ,vol. 47, pp. 874- 880 ,(1987)