Effect of Dexamethasone on Thermoresponsive Behavior of Poly(2-Oxazoline) Diblock Copolymers.
作者： Zuzana Kroneková , Leonid Satrapinskyy , Juraj Kronek , Helena Valentová , Dušan Chorvát
关键词: Ring-opening polymerization 、 Self-assembly 、 Raman spectroscopy 、 Chemical engineering 、 Polarized light microscopy 、 Drug carrier 、 Thermoresponsive polymers in chromatography 、 Copolymer 、 Materials science 、 Polymer
摘要: Thermoresponsive polymers play an important role in designing drug delivery systems for biomedical applications. In this contribution, the effect of encapsulated hydrophobic dexamethasone on thermoresponsive behavior diblock copolymers was studied. A small series copoly(2-oxazoline)s prepared by combining 2-n-propyl-2-oxazoline (nPrOx) and hydrophilic 2-methyl-2-oxazoline (MeOx) two ratios polymer chain lengths. The addition affected one copolymers, nPrOx20-MeOx180, aqueous medium shifting cloud point temperature to lower values. addition, formation microparticles containing observed during heating samples. morphology number were structure concentration copolymer, concentration, temperature. crystalline nature formed confirmed polarized light microscopy, confocal Raman wide-angle X-ray scattering. results demonstrate importance studying drug/polymer interactions future development carriers.
mdpi.com
sci-hub.st 参考文章(54)
Norbert Rasenack, Bernd W. Müller, Dissolution rate enhancement by in situ micronization of poorly water-soluble drugs. Pharmaceutical Research. ,vol. 19, pp. 1894- 1900 ,(2002) , 10.1023/A:1021410028371
Ruixue Liu, Michael Fraylich, Brian R. Saunders, Thermoresponsive copolymers: from fundamental studies to applications Colloid and Polymer Science. ,vol. 287, pp. 627- 643 ,(2009) , 10.1007/S00396-009-2028-X
Elisabeth Rossegger, Verena Schenk, Frank Wiesbrock, Design Strategies for Functionalized Poly(2-oxazoline)s and Derived Materials Polymers. ,vol. 5, pp. 956- 1011 ,(2013) , 10.3390/POLYM5030956
Martin Hruby, Sergey K. Filippov, Jiri Panek, Michaela Novakova, Hana Mackova, Jan Kucka, David Vetvicka, Karel Ulbrich, Polyoxazoline Thermoresponsive Micelles as Radionuclide Delivery Systems Macromolecular Bioscience. ,vol. 10, pp. 916- 924 ,(2010) , 10.1002/MABI.201000034
Zhijian He, Anita Schulz, Xiaomeng Wan, Joshua Seitz, Herdis Bludau, Daria Y. Alakhova, David B. Darr, Charles M. Perou, Rainer Jordan, Iwao Ojima, Alexander V. Kabanov, Robert Luxenhofer, Poly(2-oxazoline) based micelles with high capacity for 3rd generation taxoids: preparation, in vitro and in vivo evaluation. Journal of Controlled Release. ,vol. 208, pp. 67- 75 ,(2015) , 10.1016/J.JCONREL.2015.02.024
Kaili Lin, Chengtie Wu, Jiang Chang, Advances in synthesis of calcium phosphate crystals with controlled size and shape. Acta Biomaterialia. ,vol. 10, pp. 4071- 4102 ,(2014) , 10.1016/J.ACTBIO.2014.06.017
Ging-Ho Hsiue, Hou-Zen Chiang, Chau-Hui Wang, Tzuoh-Min Juang, Nonviral gene carriers based on diblock copolymers of poly(2-ethyl-2-oxazoline) and linear polyethylenimine. Bioconjugate Chemistry. ,vol. 17, pp. 781- 786 ,(2006) , 10.1021/BC050317U
Daria Y. Alakhova, Alexander V. Kabanov, Pluronics and MDR reversal: an update. Molecular Pharmaceutics. ,vol. 11, pp. 2566- 2578 ,(2014) , 10.1021/MP500298Q
Anthony Kermagoret, Charles-André Fustin, Maxime Bourguignon, Christophe Detrembleur, Christine Jérôme, Antoine Debuigne, One-pot controlled synthesis of double thermoresponsive N-vinylcaprolactam-based copolymers with tunable LCSTs Polymer Chemistry. ,vol. 4, pp. 2575- 2583 ,(2013) , 10.1039/C3PY00134B
Robert Luxenhofer, Gaurav Sahay, Anita Schulz, Daria Alakhova, Tatiana K. Bronich, Rainer Jordan, Alexander V. Kabanov, Structure-property relationship in cytotoxicity and cell uptake of poly(2-oxazoline) amphiphiles Journal of Controlled Release. ,vol. 153, pp. 73- 82 ,(2011) , 10.1016/J.JCONREL.2011.04.010