Anticonvulsant Effects of Intracortical Chronic Infusion of GABA in Generalized Epilepsy
作者： S. Brailowsky , C. Silva-Barrat , Ch. Ménini , D. Riche , R. Naquet
DOI: 10.1007/978-1-4684-6767-3_10
关键词: Electrophysiology 、 Generalized epilepsy 、 Baboon 、 GABAergic 、 Medicine 、 Epilepsy 、 Myoclonus 、 Anticonvulsant 、 Motor cortex 、 Neuroscience
摘要: The photosensitive baboon Papio papio affords a primate model of light-induced epilepsy in which intermittent light stimulation (ILS) induces the appearance paroxysmal discharges (PD) and bilateral myoclonus (Killam et al., 1967). electrophysiological characteristics this have been described (Menini’s chapter, book), here we will concentrate on, first, reviewing pharmacological studies that employed drugs related to GABAergic system; second, on describing our recent data using GABA itself localized, chronic infusion, and, third, new epileptogenic syndrome discovered these animals at end infusions: withdrawal syndrome.
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