Quantifying the microvascular origin of BOLD-fMRI from first principles with two-photon microscopy and an oxygen-sensitive nanoprobe.
作者： Louis Gagnon , Sava Sakadžić , Frédéric Lesage , Joseph J Musacchia , Joël Lefebvre
DOI: 10.1523/JNEUROSCI.3555-14.2015
关键词: Neuroimaging 、 Premovement neuronal activity 、 Two-photon excitation microscopy 、 Pathology 、 Bold fmri 、 Nanoprobe 、 Blood volume 、 Chemistry 、 Voxel 、 Neuroscience 、 Functional magnetic resonance imaging
摘要: The blood oxygenation level-dependent (BOLD) contrast is widely used in functional magnetic resonance imaging (fMRI) studies aimed at investigating neuronal activity. However, the BOLD signal reflects changes volume and rather than activity per se. Therefore, understanding transformation of microscopic vascular behavior into macroscopic signals foundation physiologically informed noninvasive neuroimaging. Here, we use oxygen-sensitive two-photon microscopy to measure BOLD-relevant microvascular physiology occurring within a typical rodent fMRI voxel predict from first principles using those measurements. predictive power approach illustrated by quantifying variations induced morphological folding human cortex. This framework then quantify contribution individual compartments other factors for different magnet strengths pulse sequences.
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