Suicide transport: destruction of neurons by retrograde transport of ricin, abrin, and modeccin
作者： R. Wiley , W. Blessing , D. Reis
关键词: Abrin 、 Ribosome 、 Axoplasmic transport 、 Ricin 、 Experimental strategy 、 Biophysics 、 Chemistry
摘要: Certain toxic lectins, including ricin, are retrogradely transported along neuronal processes to the cell body where they inactivate ribosomes, resulting in death. This process of "suicide transport" suggests a powerful new experimental strategy for solving neurobiological problems.
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