The Role of 5-HT2C Receptors in the Antidepressant Response: A Critical Review
作者： Cédric B.P. Martin , Michel Hamon , Laurence Lanfumey , Raymond Mongeau
DOI: 10.1159/000319513
关键词: Receptor Desensitization 、 Anxiety 、 Neuroscience 、 Psychology 、 In vitro toxicology 、 Antidepressant 、 Desensitization (medicine) 、 Receptor 、 Mrna level 、 Pharmacology 、 Neurochemical
摘要: There is evidence for altered 5-HT2C receptor function in anxiodepressive disorders and many antide-pressant drugs have a primary action at these receptors. Although the notion of desensitization following prolonged treatment with that increase synaptic availability 5-HT well anchored literature, this concept based mainly on vitro assays and/or behavioral little relevance to depression. Our objective herein provide comprehensive overview studies assessed effects antidepressant treatments Relevant neurochemical (receptor binding mRNA levels), physiological (5-HT2C-receptor-induced hyperthermia hormone release) (5-HT2C-receptor-inducedchanges feeding, anxiety, defense motor activity) data are summarized discussed. extensive analysis literature clearly evidences crucial lack investigating changes selected brain areas treatments, because adequate tools lacking. an overall receptors by has been challenged, hypothesis appears nevertheless supported clear-cut areas. Setting record straight about drug-induced should help determining which pharmacotherapeutic strategy best anxiety
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