Bactericidal activity of cefotaxime and fosfomycin in cerebrospinal fluid during the treatment of rabbit meningitis experimentally induced by methicillin-resistant staphylococcus aureus

摘要: The purpose of this study was to evaluate the therapeutic effect cefotaxime (CTX) and fosfomycin (FOS), alone or in combination, an experimental meningitis, with cerebrospinal fluid (CSF) concentrations two antibiotics reproducing those obtained human CSF during bacterial meningitis. With a dose 50 mg/kg CTX 100 FOS injected i.v. (CTX over 0.5 h 3 h), were comparable observed man. In series five rabbits per treatment group, population counted before after (two doses six-hour interval) CTX, + end infusion). By 12th hour treatment, percentage bacteria surviving compared initial 4.35% for 0.20% 0.19% FOS. Thus, it seemed that not more active than alone. another four bactericidal followed at T0, T6, T12, T24 T48 interval). variable drop count from one rabbit other occurred first 12 h, then bacteriostasis followed. FOS, quick becoming slower following 36 (0.03% 48th hour). achieved, remaining steady 48-hour period (0.001%