Inappropriate metformin prescribing in elderly type 2 diabetes mellitus (T2DM) patients.

摘要: ABSTRACT Purpose Metformin is the most commonly prescribed anti-diabetic medication. However, it often used despite presence of contraindications and in unlicensed indications. The main aim this study was to evaluate frequency metformin use before hospitalization spite patients with type 2 diabetes mellitus (T2DM) prevalence - associated side effects. Material/Methods 558 hospitalized (mean age = 66.65±12.73 years) poorly controlled T2DM were enrolled. Detailed medical history including duration T2DM, hypoglycemic agents usage prior possible metformin-associated effects recorded. Patients subjected a thorough physical examination indispensable biochemical diagnostic research panel performed establish degree heart failure, sufficiency respiratory system kidney function. Results 335 out treated alone or combination other agents, mostly sulfonylureas. Contraindications found 275 120 them using medication an average dose 1793.91±701.61 mg. none reported any serious adverse no significant pH changes observed. Only three moderate dyspepsia. Conclusions results indicate relatively good tolerability by traditional drug. These findings support authors’ suggestion that indications should be re-evaluated.