Correlation between elevation of serum antinuclear antibody titer and decreased therapeutic efficacy in the treatment of Behçet’s disease with infliximab
作者： Daiju Iwata , Kenichi Namba , Kazuomi Mizuuchi , Nobuyoshi Kitaichi , Satoru Kase
DOI: 10.1007/S00417-011-1908-1
关键词: Titer 、 Medicine 、 Monoclonal 、 Anti-nuclear antibody 、 Antibody 、 Immunology 、 Uveitis 、 Therapeutic effect 、 Behcet's disease 、 Infliximab
摘要: Background Infliximab, an anti-TNF-α monoclonal antibody, administered to Behcet’s disease (BD) patients in Japan with refractory intraocular inflammation, has shown excellent clinical results. However, some demonstrate a decreased response infliximab during the course of treatment. In present study, we investigated correlation between this reduced therapeutic effect and elevation serum antinuclear antibody (ANA) titers BD who were undergoing therapy.
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