The Immunosuppressive Role of Adenosine A2A Receptors in Ischemia Reperfusion Injury and Islet Transplantation

摘要: Activation of adenosine A2A receptors (A2AR) reduces inflammation by generally inhibiting the activation pro-inflammatory cells, decreasing endothelial adhesion molecule expression and reducing release proinflammatory cytokine mediators. Numerous preclinical studies using selective A2AR agonists, antagonists, knockout as well chimeric mice have suggested therapeutic potential agonists for treatment ischemia reperfusion injury (IRI) autoimmune diseases. This review summarizes immunosuppressive actions in murine IRI models liver, kidney, heart, lung CNS, gives details on cellular effects neutrophils, macrophages, dendritic natural killer NKT T effector cells CD4+CD25+FoxP3+ regulatory cells. is discussed context mediators involved inflammatory cascades. Whilst role receptor various disease has been well-documented, very little information available regarding type 1 diabetes mellitus (T1DM). An overview pathogenesis T1DM early islet graft rejection immediate peri-transplantation period offers insight use a beneficial intervention clinical transplantation, promoting survival, minimizing loss number islets required successful thereby increasing availability this procedure to greater recipients. In summary, an adjunct immunesuppressive regimen transplantation highlighted.