Synthesis of Ketones by C−H Functionalization of Aldehydes with Boronic Acids under Transition-Metal-Free Conditions
作者： Aurelio G. Csáky , Silvia Roscales
关键词: Reagent 、 Intramolecular force 、 Aldehyde 、 Boronic acid 、 Surface modification 、 Combinatorial chemistry 、 Iminium 、 Chemistry 、 Nitrosobenzene 、 Transition metal
摘要: A method for the synthesis of ketones from aldehydes and boronic acids via a transition-metal-free C-H functionalization reaction is reported. The employs nitrosobenzene as reagent to drive simultaneous activation acid boronate bond aldehyde an iminium species that triggers key C-C bond-forming step intramolecular migration boron carbon. These findings constitute practical, scalable, operationally straightforward ketones.
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