Aging and the physiology of spatial memory.
作者： C.A. Barnes
DOI: 10.1016/S0197-4580(88)80114-3
关键词: Electrophysiology 、 Information processing 、 Hippocampal formation 、 Cognitive impairment 、 Neuroscience 、 Cognitive decline 、 Spatial memory 、 Hippocampus 、 Psychology
摘要: Evidence for age-related changes in spatial memory rodents and humans is presented, along with data that suggest the hippocampal formation necessary normal performance on tasks both species. An examination of electrophysiological characteristics this structure rats suggests occur age hippocampus are selective, but at least two primary types alterations contribute to cognitive impairment seen these animals. These include a deficit ability maintain synaptic enhancement reduction accuracy information processing single neurons.
elsevier.com
sci-hub.se 参考文章(59)
Barnes Ca, Green Ej, Johnson We, Baldwin J, Behavioural and neurophysiological examples of functional sparing in senescent rat. Canadian Journal of Psychology\/revue Canadienne De Psychologie. ,vol. 41, pp. 131- 140 ,(1987)
C.A. Barnes, B.L. McNaughton, Excitability Changes in Hippocampal Granule Cells of Senescent Rat Progress in Brain Research. ,vol. 58, pp. 445- 451 ,(1983) , 10.1016/S0079-6123(08)60047-3
T. L�mo, Patterns of activation in a monosynaptic cortical pathway : the perforant path input to the dentate area of the hippocampal formation Experimental Brain Research. ,vol. 12, pp. 18- 45 ,(1971) , 10.1007/BF00234414
FH Gage, A Bjorklund, Cholinergic septal grafts into the hippocampal formation improve spatial learning and memory in aged rats by an atropine-sensitive mechanism The Journal of Neuroscience. ,vol. 6, pp. 2837- 2847 ,(1986) , 10.1523/JNEUROSCI.06-10-02837.1986
S Zola-Morgan, LR Squire, DG Amaral, Human amnesia and the medial temporal region: enduring memory impairment following a bilateral lesion limited to field CA1 of the hippocampus The Journal of Neuroscience. ,vol. 6, pp. 2950- 2967 ,(1986) , 10.1523/JNEUROSCI.06-10-02950.1986
G. Rao, C.A. Barnes, B.L. McNaughton, Intracellular fluorescent staining with carboxyfluorescein: a rapid and reliable method for quantifying dye-coupling in mammalian central nervous system Journal of Neuroscience Methods. ,vol. 16, pp. 251- 263 ,(1986) , 10.1016/0165-0270(86)90050-6
C. A. Barnes, B. L. McNaughton, Neurophysiological comparison of dendritic cable properties in adolescent, middle-aged, and senescent rats Experimental Aging Research. ,vol. 5, pp. 195- 206 ,(1979) , 10.1080/03610737908257198
J. E. Wallace, E. E. Krauter, B. A. Campbell, Animal models of declining memory in the aged: short-term and spatial memory in the aged rat. Journal of Gerontology. ,vol. 35, pp. 355- 363 ,(1980) , 10.1093/GERONJ/35.3.355
Gordon Winocur, The hippocampus and cue utilization Physiological Psychology. ,vol. 8, pp. 280- 288 ,(1980) , 10.3758/BF03332859
Kathy Pezdek, Memory for items and their spatial locations by young and elderly adults. Developmental Psychology. ,vol. 19, pp. 895- 900 ,(1983) , 10.1037/0012-1649.19.6.895