Altered immune responses in mice lacking inducible nitric oxide synthase

摘要: NITRIC oxide (NO) is important in many biological functions1–5. It generated from L-arginine by the enzyme NO synthase (NOS). The cytokine-inducible NOS (iNOS) activated several immunological stimuli, leading to production of large quantities which can be cytotoxic6. To define role iNOS further, we mutant mice. These are viable, fertile and without evident histopathological abnormalities. However, contrast wild-type heterozygous mice, highly resistant protozoa parasite Leishmania major infection, mice uniformly susceptible. infected developed a significantly stronger Thl type immune response than or showed reduced nonspecific inflammatory carrageenin, were lipopolysaccharide-induced mortality.