Modulation of synaptic vesicle exocytosis in muscle-dependent long-term depression at the amphibian neuromuscular junction.
作者： Sarah J. Etherington , Victoria P. A. Johnstone , Alan W. Everett
DOI: 10.1371/JOURNAL.PONE.0087174
关键词: Synaptic vesicle 、 Cell biology 、 Synaptic plasticity 、 Internal medicine 、 Long-term depression 、 Endocrinology 、 Exocytosis 、 Neuromuscular junction 、 Long-Term Synaptic Depression 、 Kiss-and-run fusion 、 Synaptic vesicle exocytosis 、 Biology
摘要: We have labeled recycling synaptic vesicles at the somatic Bufo marinus neuromuscular junction with styryl dye FM2-10 and provide direct evidence for refractoriness of exocytosis associated a muscle activity-dependent form long-term depression (LTD) this synapse. unloading experiments demonstrated that rate vesicle from release ready pool (RRP) was more than halved in LTD (induced by 20 min low frequency stimulation). Recovery LTD, observed as partial recovery nerve-evoked twitch amplitude, accompanied RRP exocytosis. Unexpectedly, paired pulse plasticity, another routinely used indicator presynaptic forms unchanged LTD. conclude induces machinery downstream calcium entry.
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