Effects of clozapine on cerebral catecholaminergic neurone systems
作者： G. BARTHOLINI , W. HAEFELY , M. JALFRE , H. H. KELLER , A. PLETSCHER
DOI: 10.1111/J.1476-5381.1972.TB06898.X
关键词: Catalepsy 、 Extrapyramidal disorder 、 Receptor 、 Blockade 、 Medicine 、 Clozapine 、 Antipsychotic 、 Dopamine 、 Catecholaminergic 、 Pharmacology
摘要: Summary 1 . Clozapine, a dibenzodiazepine derivative claimed to possess antipsychotic properties in man without producing extrapyramidal disorders, greatly increased the turnover of cerebral dopamine rat. 2 . The drug itself was virtually devoid cataleptigenic activity rats; however, it antagonized prochlorperazine-induced catalepsy. 3 . It is proposed that clozapine causes blockade striatal receptors which surmountable type contrast produced by neuroleptics. In addition, may also increase noradrenaline.
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