Molecular genetics of pineal region neoplasms.

摘要: A large variety of mass lesions have been reported in the region pineal gland. Pineal parenchymal tumors and germ cell (GCTs) are especially characteristic this region. Despite their rarity, a number excellent studies on cytogenetics molecular genetics GCTs published. These draw attention to distinct genomic regions recurrently involved various subtypes malignancies Outcomes for location vary widely between patients among differing histologies. Development novel therapies with poor prognoses will depend acquisition more detailed understanding basis associated etiopathogenesis these neoplasms. We review literature cytogenetics, familial syndromes, animal models