作者: Yahua Chen , Janice Succi , Fred C. Tenover , Theresa M. Koehler
DOI: 10.1128/JB.185.3.823-830.2003
关键词: Microbiology 、 Cereus 、 Clavulanic acid 、 Plasmid 、 Penicillin 、 Anthrax toxin 、 Biology 、 Bacillus cereus 、 Virulence 、 Bacillus anthracis
摘要: Susceptibility to penicillin and other β-lactam-containing compounds is a common trait of Bacillus anthracis. β-lactam agents, particularly penicillin, have been used worldwide to treat anthrax in humans. Nonetheless, surveys of clinical and soil-derived strains reveal penicillin G resistance in 2 to 16% of isolates tested. Bacterial resistance to β-lactam agents is often mediated by production of one or more types of β-lactamases that hydrolyze the β-lactam ring, inactivating the antimicrobial agent. Here, we report the presence of two β-lactamase …