β-Lactamase Genes of the Penicillin-Susceptible Bacillus anthracis Sterne Strain

作者: Yahua Chen , Janice Succi , Fred C. Tenover , Theresa M. Koehler

DOI: 10.1128/JB.185.3.823-830.2003

关键词: MicrobiologyCereusClavulanic acidPlasmidPenicillinAnthrax toxinBiologyBacillus cereusVirulenceBacillus anthracis

摘要: Susceptibility to penicillin and other β-lactam-containing compounds is a common trait of Bacillus anthracis. β-lactam agents, particularly penicillin, have been used worldwide to treat anthrax in humans. Nonetheless, surveys of clinical and soil-derived strains reveal penicillin G resistance in 2 to 16% of isolates tested. Bacterial resistance to β-lactam agents is often mediated by production of one or more types of β-lactamases that hydrolyze the β-lactam ring, inactivating the antimicrobial agent. Here, we report the presence of two β-lactamase …

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