Dependence of Polymorphic Transformation on Anti-Solvent Composition and Crystallization Behavior of Thiazole-Derivative Pharmaceutical

摘要: The transformation and crystallization behaviors of the polymorphs (A C) solvated crystals (BH (BPT·0.5H2O) D (BPT·MeOH)) thiazole-derivative pharmaceutical (BPT) were investigated. solubility metastable form was measured with vigorous stirring using a magnetic stirrer. It found that at 323 K volume fraction methanol (VMeOH) 0.5, A forms dose not transform to stable C directly, but in two steps via BH form. stability tended decrease increased decreased temperature from 303 K. also transformed 313 This is because selective nucleation growth due specific solute-solvent interaction comparison crystals. small free energy difference between stabilizes form.It appeared composition ranges 0.5–0.8 At 0.7 A, form, C. With increase decreased. Such tendency may be dissociation crystals.In by adding water as an anti-solvent BPT solution mixture, it cleared only crystallize ratio these depends on addition rate water. Further more, transforms solution-mediated mechanism after crystallization.