The C-type lectin-like domain superfamily

作者: Alex N Zelensky , Jill E Gready

DOI: 10.1111/J.1742-4658.2005.05031.X

关键词: Protein structureComputational biologyProtein superfamilyAlpha helixBiologyPhylogeneticsFunction (biology)C-type lectinBinding siteBiochemistryMolecular evolution

摘要: The superfamily of proteins containing C‐type lectin‐like domains (CTLDs) is a large group of extracellular Metazoan proteins with diverse functions. The CTLD structure has a characteristic double‐loop ('loop‐in‐a‐loop') stabilized by two highly conserved disulfide bridges located at the bases of the loops, as well as a set of conserved hydrophobic and polar interactions. The second loop, called the long loop region, is structurally and evolutionarily flexible, and is involved in Ca2+‐dependent carbohydrate binding and …

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