Interferon activity and its characterization in the sera of patients with head and neck cancer.

摘要: The interferon (IFN) assay of the sera from 40 patients with head and neck cancer was performed by plaque-reduction vesicular stomatitis virus in FL cells derived human amniotic membrane. mainly had Stage III or IV lesion without distant metastasis, previously not received any therapy. All were histologically diagnosed as squamous cell carcinoma. When serum IFN activity characterized acid treatment, significant increases IFN-α/β/γ (n = 24, P < 0.05) acid-labile 0.001), decrease acid-stable 0.001) 50-to-79-year age group found, compared those normal controls same 20). titers including various immunologic parameters simultaneously assayed prior to beginning therapy, IFN-α/β/γ, IFN, significantly correlated some such natural killer (NK) activity, absolute number Tγ lymphocytes, percentages β- γ-globulin, amounts IgA, IgG, IgM, β2 microglobulin. To define further nature this both donors a neutralization an antiserum HuIFN-α HUIFN-β. left when testing neutralized these antisera expressed γ-like IFN. 0.0001) showed highly increase correlation between prognosis disease investigated measuring patients, all nine good after treatment decreased levels (P 0.01) on time before On other hand, six recurrent measurement therapy 0.05). These findings led us suggest that levels, especially may be associated function loops immune system cancer.