Challenges in the design of insulin and relaxin/insulin-like peptide mimetics.
作者： Mohammed Akhter Hossain , Ross A.D. Bathgate
DOI: 10.1016/J.BMC.2017.09.030
关键词: Drug discovery 、 Receptor 、 Chemistry 、 Peptidomimetic 、 Insulin 、 Peptide sequence 、 Peptide 、 Relaxin/insulin-like family peptide receptor 2 、 Relaxin 、 Biochemistry
摘要: … Then minimization of the structure and introduction of constraints are applied to create the core active site that can interact with the target with high affinity and selectivity. Developing …
sci-hub.se 参考文章(109)
Niall Hd, Bryant-Greenwood Gd, Bradshaw Ra, Relaxin: an insulin-related growth factor. Progress in Clinical and Biological Research. ,vol. 31, pp. 651- ,(1979)
T Kurose, M Pashmforoush, Y Yoshimasa, R Carroll, G P Schwartz, G T Burke, P G Katsoyannis, D F Steiner, Cross-linking of a B25 azidophenylalanine insulin derivative to the carboxyl-terminal region of the alpha-subunit of the insulin receptor. Identification of a new insulin-binding domain in the insulin receptor. Journal of Biological Chemistry. ,vol. 269, pp. 29190- 29197 ,(1994) , 10.1016/S0021-9258(19)62029-6
Colin W. Ward, John G. Menting, Michael C. Lawrence, The insulin receptor changes conformation in unforeseen ways on ligand binding: Sharpening the picture of insulin receptor activation BioEssays. ,vol. 35, pp. 945- 954 ,(2013) , 10.1002/BIES.201300065
DORINE CHASSIN, ANNE LAURENT, JEAN-LOUIS JANNEAU, ROLAND BERGER, DOMINIQUE BELLET, Cloning of a new member of the insulin gene superfamily (INSL4) expressed in human placenta Genomics. ,vol. 29, pp. 465- 470 ,(1995) , 10.1006/GENO.1995.9980
E.E. Büllesbach, C. Schwabe, Total synthesis of human relaxin and human relaxin derivatives by solid-phase peptide synthesis and site-directed chain combination. Journal of Biological Chemistry. ,vol. 266, pp. 10754- 10761 ,(1991) , 10.1016/S0021-9258(18)99082-4
Tracey N Wilkinson, Terence P Speed, Geoffrey W Tregear, Ross AD Bathgate, Evolution of the relaxin-like peptide family BMC Evolutionary Biology. ,vol. 5, pp. 14- 14 ,(2005) , 10.1186/1471-2148-5-14
E.E. Büllesbach, S Yang, C Schwabe, The receptor-binding site of human relaxin II. A dual prong-binding mechanism. Journal of Biological Chemistry. ,vol. 267, pp. 22957- 22960 ,(1992) , 10.1016/S0021-9258(18)50040-5
I M Adham, E Burkhardt, M Benahmed, W Engel, Cloning of a cDNA for a novel insulin-like peptide of the testicular Leydig cells. Journal of Biological Chemistry. ,vol. 268, pp. 26668- 26672 ,(1993) , 10.1016/S0021-9258(19)74364-6
R.J. Crawford, P. Hudson, J. Shine, H.D. Niall, R.L. Eddy, T.B. Shows, Two human relaxin genes are on chromosome 9. The EMBO Journal. ,vol. 3, pp. 2341- 2345 ,(1984) , 10.1002/J.1460-2075.1984.TB02136.X
Erika E. Büllesbach, Christian Schwabe, The trap-like relaxin-binding site of the leucine-rich G-protein-coupled receptor 7. Journal of Biological Chemistry. ,vol. 280, pp. 14051- 14056 ,(2005) , 10.1074/JBC.M500030200