Cisplatin induces PKB/Akt activation and p38(MAPK) phosphorylation of the EGF receptor.

作者: S E Winograd-Katz , A Levitzki

DOI: 10.1038/SJ.ONC.1209737

关键词: Internal medicineProto-oncogene tyrosine-protein kinase SrcEndocrinologyThreonineBiologyCancer cellPhosphorylationCisplatinInternalizationProtein kinase BEpidermal growth factor receptorCancer research

摘要: … , as measured by T308 phosphorylation, and that this activation is … also the p38 MAPK, which we found to phosphorylate the … through the phosphorylation of threonine 669 by p38 MAPK. …

参考文章(29)
Eugene S. Kandel, Nissim Hay, The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB. Experimental Cell Research. ,vol. 253, pp. 210- 229 ,(1999) , 10.1006/EXCR.1999.4690
Kunio Takishima, BethAnn Friedman, Hirota Fujiki, Marsha Rich Rosner, Thapsigargin, a novel promoter, phosphorylates the epidermal growth factor receptor at threonine 669. Biochemical and Biophysical Research Communications. ,vol. 157, pp. 740- 746 ,(1988) , 10.1016/S0006-291X(88)80312-7
A. V. Vieira, C. Lamaze, S. L. Schmid, Control of EGF Receptor Signaling by Clathrin-Mediated Endocytosis Science. ,vol. 274, pp. 2086- 2089 ,(1996) , 10.1126/SCIENCE.274.5295.2086
Meiyun Fan, Timothy C. Chambers, Role of mitogen-activated protein kinases in the response of tumor cells to chemotherapy Drug Resistance Updates. ,vol. 4, pp. 253- 267 ,(2001) , 10.1054/DRUP.2001.0214
Thomas F Franke, Sung-Il Yang, Tung O Chan, Ketaki Datta, Andrius Kazlauskas, Deborah K Morrison, David R Kaplan, Philip N Tsichlis, The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase Cell. ,vol. 81, pp. 727- 736 ,(1995) , 10.1016/0092-8674(95)90534-0
Pramod Pandey, Joel Raingeaud, Masao Kaneki, Ralph Weichselbaum, Roger J. Davis, Donald Kufe, Surender Kharbanda, Activation of p38 Mitogen-activated Protein Kinase by c-Abl-dependent and -independent Mechanisms Journal of Biological Chemistry. ,vol. 271, pp. 23775- 23779 ,(1996) , 10.1074/JBC.271.39.23775
Jing Bao, Iris Alroy, Hadassa Waterman, Eyal D. Schejter, Chaya Brodie, Jean Gruenberg, Yosef Yarden, Threonine phosphorylation diverts internalized epidermal growth factor receptors from a degradative pathway to the recycling endosome. Journal of Biological Chemistry. ,vol. 275, pp. 26178- 26186 ,(2000) , 10.1074/JBC.M002367200
Maria Kartalou, John M Essigmann, Mechanisms of resistance to cisplatin. Mutation Research. ,vol. 478, pp. 23- 43 ,(2001) , 10.1016/S0027-5107(01)00141-5
T. Ingebritsen, M. R. Rosner, K. Takishima, I. Griswold-Prenner, Epidermal growth factor (EGF) receptor T669 peptide kinase from 3T3-L1 cells is an EGF-stimulated "MAP" kinase. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 88, pp. 2520- 2524 ,(1991) , 10.1073/PNAS.88.6.2520