Glibenclamide, a Selective Inhibitor of ATP-Sensitive K+ Channels, Attenuates Metabolic Coronary Vasodilatation Induced by Pacing Tachycardia in Dogs

摘要: Background We previously reported that glibenclamide (a selective inhibitor of ATP-sensitive K+ channels [K+ATP channels]) inhibited metabolic coronary vasodilatation induced by β1-adrenoceptor stimulation. However, the role K+ATP in tachycardia is still unknown. This study aimed to determine whether attenuates pacing-induced tachycardia. Methods and Results In anesthetized dogs, increasing heart rate from 103±1 160 beats per minute with atrial pacing increased blood flow without altering arterial pressure left ventricular pressure. Intracoronary infusion at 1.5 5.0 μg · kg−1 min−1 did not alter basal but significantly attenuated (P<.01) tachycardia-induced increase myocardial oxygen consumption (MVo2). conscious intracoronary ...