Pharmaceutical composition for oral administration
作者： Akio Sugihara , Takehiko Yasuji , Hiroyuki Yoshino , Noriyuki Kinoshita , Kazuhiro Sako
DOI:
关键词: Composition (visual arts) 、 Dissolution testing 、 Solubility 、 Chromatography 、 Materials science 、 Oral administration 、 Drug dosing 、 Neutral ph 、 Salt (chemistry) 、 Active ingredient 、 Combinatorial chemistry
摘要: A pharmaceutical composition containing, as the active ingredient, 4-{[(1R,2s,3S,5s,7s)-5-hydroxy-2-adamantyl]amino}-1H-pyrrolo[2,3-b]pyridine-5-carboxamide, of which solubility in an acidic pH region is different from that a neutral region, with rapid disintegration property and drug dissolution well expectation good dosing compliance, provided. The for oral administration present invention contains 4-{[(1R,2s,3S,5s,7s)-5-hydroxy-2-adamantyl]amino}-1H-pyrrolo[2,3-b]pyridine-5-carboxamide or pharmaceutically acceptable salt thereof, hydrophilic lubricant, useful compliance.
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