Contribution of the latent transforming growth factor-β binding protein 2 gene to etiology of primary open angle glaucoma and pseudoexfoliation syndrome.
作者： Sahar Jelodari-Mamaghani , Ramona Haji-Seyed-Javadi , Elahe Elahi , Fatemeh Suri , Kambiz Kamyab
DOI:
关键词: Extracellular matrix 、 Genetics 、 Pseudoexfoliation 、 Biology 、 Open angle glaucoma 、 Glaucoma 、 Latent TGF-beta binding protein 、 Pseudoexfoliation syndrome 、 Cancer research 、 Transforming growth factor 、 Binding protein
摘要: Purpose To assess for the first time possible contribution of latent transforming growth factor (TGF)-beta binding protein 2 (LTBP2), an extracellular matrix (ECM) that associates with fibrillin-1-containing microfibrils, to etiology primary open angle glaucoma (POAG) and pseudoexfoliation (PEX) syndrome. Mutations in LTBP2 have previously been shown be cause congenital (PCG) other disorders often manifest as secondary glaucoma.
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