A fumonisin biosynthetic gene cluster in Fusarium oxysporum strain O-1890 and the genetic basis for B versus C fumonisin production
作者： Robert H. Proctor , Mark Busman , Jeong-Ah Seo , Yin Won Lee , Ronald D. Plattner
DOI: 10.1016/J.FGB.2008.02.004
关键词: Complementation 、 Gene cluster 、 Fumonisin 、 Mutant 、 Biology 、 Fusarium oxysporum 、 Fusarium proliferatum 、 Fungal genetics 、 Microbiology 、 Fusarium
摘要: Most species of Fusarium that produce fumonisin mycotoxins predominantly B fumonisins (FBs). However, oxysporum strain O-1890 produces C (FCs). In this study, the nucleotide sequence biosynthetic gene (FUM) cluster in was determined. The order and orientation FUM genes were same as previously described clusters verticillioides proliferatum. Coding regions F. 88-92% identical, but flanking did not share significant identity. FUM8 encodes an alpha-oxoamine synthase, fum8 mutants do fumonisins. Complementation a mutant with verticillioidesFUM8 restored FB production. oxysporumFUM8 also production, produced FCs. These data indicate different orthologues determine whether FBs or
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