Proteolytic control of regulated necrosis

摘要: Proteases control most of the physiological processes that occur in a cell. This particularly applies to apoptosis, well-studied form cell death, where proteolysis by cysteine-aspartic proteases (caspases) is primary mechanism for both initiation and execution suicide. In contrast, impact on other, non-apoptotic death pathways (summarized under term "regulated necrosis", RN) has long been enigmatic, but clearly confirmed number recent groundbreaking discoveries. Here, we review these discoveries provide an overview role known forms RN, with particular focus necroptosis pyroptosis, their regulation deubiquitinases, apoptotic inflammatory caspases. article part Special Issue entitled: Proteolysis as Regulatory Event Pathophysiology edited Stefan Rose-John.