Mechanism of ESAT-6 membrane interaction and its roles in pathogenesis of Mycobacterium tuberculosis
作者： Xiuli Peng , Jianjun Sun
DOI: 10.1016/J.TOXICON.2015.10.003
关键词: Pathogenesis 、 Antigen 、 Secretion 、 Biology 、 Cell membrane 、 Cell biology 、 ESAT-6 、 Immunology 、 Virulence 、 Pore-forming toxin 、 Mycobacterium tuberculosis
摘要: The 6-kDa early secreted antigenic target (ESAT-6; EsxA) of Mycobacterium tuberculosis was first identified as a potent T-cell antigen, and it is now recognized pore-forming toxin that essential for virulence M. tuberculosis. ESAT-6 through the ESX-1 secretion system (Type VII) M. tuberculosis has been implicated to mediate mycobacterial cytosolic translocation within host macrophages by rupturing phagosomal membranes. Recent studies have made significant progresses in understanding mechanism membrane interaction its role pathogenesis, but important questions still remain be answered. Here, we summarize current progress study roles pathogenesis discuss some key remaining future investigation.
sci-hub.se 参考文章(64)
Anthony A. Ryan, Jonathan K. Nambiar, Teresa M. Wozniak, Ben Roediger, Elena Shklovskaya, Warwick J. Britton, Barbara Fazekas de St. Groth, James A. Triccas, Antigen Load Governs the Differential Priming of CD8 T Cells in Response to the Bacille Calmette Guérin Vaccine or Mycobacterium tuberculosis Infection Journal of Immunology. ,vol. 182, pp. 7172- 7177 ,(2009) , 10.4049/JIMMUNOL.0801694
Amira Refai, Meriam Haoues, Houcemeddine Othman, Mohamed Ridha Barbouche, Philippe Moua, Arnaud Bondon, Liza Mouret, Najet Srairi-Abid, Makram Essafi, Two distinct conformational states of Mycobacterium tuberculosis virulent factor early secreted antigenic target 6 kDa are behind the discrepancy around its biological functions. FEBS Journal. ,vol. 282, pp. 4114- 4129 ,(2015) , 10.1111/FEBS.13408
Sarah A. Stanley, James E. Johndrow, Paolo Manzanillo, Jeffery S. Cox, The Type I IFN response to infection with Mycobacterium tuberculosis requires ESX-1-mediated secretion and contributes to pathogenesis. Journal of Immunology. ,vol. 178, pp. 3143- 3152 ,(2007) , 10.4049/JIMMUNOL.178.5.3143
Javier Pizarro-Cerdá, Pascale Cossart, Bacterial Adhesion and Entry into Host Cells Cell. ,vol. 124, pp. 715- 727 ,(2006) , 10.1016/J.CELL.2006.02.012
Philip S. Renshaw, Parthena Panagiotidou, Adam Whelan, Stephen V. Gordon, R. Glyn Hewinson, Richard A. Williamson, Mark D. Carr, Conclusive evidence that the major T-cell antigens of the Mycobacterium tuberculosis complex ESAT-6 and CFP-10 form a tight, 1:1 complex and characterization of the structural properties of ESAT-6, CFP-10, and the ESAT-6*CFP-10 complex. Implications for pathogenesis and virulence. Journal of Biological Chemistry. ,vol. 277, pp. 21598- 21603 ,(2002) , 10.1074/JBC.M201625200
Gopalkrishna Sreejit, Asma Ahmed, Nazia Parveen, Vishwanath Jha, Vijaya Lakshmi Valluri, Sudip Ghosh, Sangita Mukhopadhyay, The ESAT-6 Protein of Mycobacterium tuberculosis Interacts with Beta-2-Microglobulin (β2M) Affecting Antigen Presentation Function of Macrophage PLoS Pathogens. ,vol. 10, pp. e1004446- ,(2014) , 10.1371/JOURNAL.PPAT.1004446
Alexander S. Pym, Priscille Brodin, Laleh Majlessi, Roland Brosch, Caroline Demangel, Ann Williams, Karen E. Griffiths, Gilles Marchal, Claude Leclerc, Stewart T. Cole, Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis. Nature Medicine. ,vol. 9, pp. 533- 539 ,(2003) , 10.1038/NM859
Joaquin De Leon, Guozhong Jiang, Yue Ma, Eric Rubin, Sarah Fortune, Jianjun Sun, Mycobacterium tuberculosis ESAT-6 Exhibits a Unique Membrane-interacting Activity That Is Not Found in Its Ortholog from Non-pathogenic Mycobacterium smegmatis Journal of Biological Chemistry. ,vol. 287, pp. 44184- 44191 ,(2012) , 10.1074/JBC.M112.420869
Sabine Daugelat, Jane Kowall, Jens Mattow, Dirk Bumann, Ralf Winter, Robert Hurwitz, Stefan H.E. Kaufmann, The RD1 proteins of Mycobacterium tuberculosis: expression in Mycobacterium smegmatis and biochemical characterization Microbes and Infection. ,vol. 5, pp. 1082- 1095 ,(2003) , 10.1016/S1286-4579(03)00205-3
Roxane Simeone, Fadel Sayes, Okryul Song, Matthias I. Gröschel, Priscille Brodin, Roland Brosch, Laleh Majlessi, Cytosolic Access of Mycobacterium tuberculosis: Critical Impact of Phagosomal Acidification Control and Demonstration of Occurrence In Vivo PLOS Pathogens. ,vol. 11, ,(2015) , 10.1371/JOURNAL.PPAT.1004650