Importance of the Bcl-2 family in cell death regulation

摘要: Bcl-2 was first identified as a novel transcript associated with the t(14;18) chromosomal breakpoint which occurs in most follicular lymphomas. The deregulated expression of bcl-2 found to contribute multistep neoplasia through suppression cell death, or apoptosis, transgenic mouse models. subsequently shown be normally expressed variety tissues and significantly inhibit induction apoptosis many experimental systems. is now known structurally similar other proteins, particular within domains referred BH1 BH2. This multigene family death regulators includes members enhance rates including bcl-xs bax, those MCL-1 bcl-xl. Members physically interact these interactions appear modulate their function. mechanism(s) by regulate remain large part unknown, although recent evidence suggests that may interfere cellular signalling events involved induction.