Oral toxic exposure of titanium dioxide nanoparticles on serum biochemical changes in adult male Wistar rats
作者： Venugopal Ramalingam , Dasal Vasantharaja , Gaddam Aadinaath Reddy
关键词: Uric acid 、 Materials science 、 Blood urea nitrogen 、 Endocrinology 、 Aspartate transaminase 、 Toxicity 、 Alkaline phosphatase 、 Bilirubin 、 Internal medicine 、 Albumin 、 Alanine transaminase
摘要: Objective(s): Titanium dioxide (TiO2) nanoparticles (NPs) are widely used in commercial food additives and cosmetics worldwide. Uptake of these nanoparticulate into humans by different routes may exhibit potential side effects, lags behind the rapid development nanotechnology. Thus, present study designed to evaluate toxic effect mixed rutile anatase TiO2 NPs on serum biochemical changes rats. Materials Methods: In this study, adult male Wistar rats were randomly allotted experimental control groups (n=6), which orally administered with 50 100 mg/kg body weight NPs. Toxic effects assessed parameters such as glucose, total protein, albumin, globulin, cholesterol, triglyceride, high density lipoprotein, alanine transaminase, aspartate alkaline phosphatase, bilirubin, blood urea nitrogen, uric acid creatinine. All markers experimented rats, after 14-days post exposure. Results: Changes specific indicated that liver kidney significantly affected both groups. The between levels transaminase phosphatase indicate induces damage. Significant increase nitrogen indicates renal damage treated Conclusion: data shows oral administration (<100nm) lead hepatic toxicity
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