Regulation of adult bone turnover by sex steroids.
作者： Baruch Frenkel , Albert Hong , Sanjeev K. Baniwal , Gerhard A. Coetzee , Claes Ohlsson
DOI: 10.1002/JCP.22159
关键词: Endocrinology 、 RUNX2 、 Bone resorption 、 Bone remodeling 、 Osteoclast 、 Osteoporosis 、 Internal medicine 、 Estrogen 、 RANKL 、 Biology 、 Fas ligand
摘要: Recent reports reveal increasing complexity of mechanisms underlying the bone sparing effects sex steroids. This review focuses on by which steroids attenuate endocortical and trabecular adult turnover, perhaps their most important property as mass regulators. Clearly, estrogen withdrawal increases osteoclast number resorption; however, open questions are extent to osteoblasts precursors involved, relative contributions RANK/RANKL/OPG system, Fas ligand Runx2. In addition reviewing these aspects action, we also discuss proskeletal androgens male skeleton, including aromatization estrogens male-specific mechanisms. Detailed understanding skeletal site- gender-dependent protect skeleton will provide foundation for improved risk assessment, prevention management osteoporosis. J. Cell. Physiol. 224: 305–310, 2010. © 2010 Wiley-Liss, Inc.
sci-hub.se 参考文章(65)
A. Ray, K.E. Prefontaine, P. Ray, Down-modulation of interleukin-6 gene expression by 17 beta-estradiol in the absence of high affinity DNA binding by the estrogen receptor. Journal of Biological Chemistry. ,vol. 269, pp. 12940- 12946 ,(1994) , 10.1016/S0021-9258(18)99966-7
Sundeep Khosla, Estrogen and bone: Insights from estrogen-resistant, aromatase-deficient, and normal men Bone. ,vol. 43, pp. 414- 417 ,(2008) , 10.1016/J.BONE.2008.05.005
Joseph Lorenzo, Mark Horowitz, Yongwon Choi, Osteoimmunology: interactions of the bone and immune system. Endocrine Reviews. ,vol. 29, pp. 403- 440 ,(2008) , 10.1210/ER.2007-0038
Vincenzo Rochira, Lucia Zirilli, Bruno Madeo, Claudio Aranda, Giovanni Caffagni, Bibiana Fabre, Victor E. Montangero, Emilio J.A. Roldan, Laura Maffei, Cesare Carani, Skeletal effects of long-term estrogen and testosterone replacement treatment in a man with congenital aromatase deficiency: Evidences of a priming effect of estrogen for sex steroids action on bone ☆ Bone. ,vol. 40, pp. 1662- 1668 ,(2007) , 10.1016/J.BONE.2007.01.022
Lorenz C. Hofbauer, Francesca Gori, B. Lawrence Riggs, David L. Lacey, Colin R. Dunstan, Thomas C. Spelsberg, Sundeep Khosla, Stimulation of osteoprotegerin ligand and inhibition of osteoprotegerin production by glucocorticoids in human osteoblastic lineage cells: potential paracrine mechanisms of glucocorticoid-induced osteoporosis. Endocrinology. ,vol. 140, pp. 4382- 4389 ,(1999) , 10.1210/ENDO.140.10.7034
R L Jilka, K Takahashi, M Munshi, D C Williams, P K Roberson, S C Manolagas, Loss of estrogen upregulates osteoblastogenesis in the murine bone marrow. Evidence for autonomy from factors released during bone resorption. Journal of Clinical Investigation. ,vol. 101, pp. 1942- 1950 ,(1998) , 10.1172/JCI1039
Liesbeth Vandenput, Johannes V Swinnen, Steven Boonen, Erik Van Herck, Reinhold G Erben, Roger Bouillon, Dirk Vanderschueren, Role of the androgen receptor in skeletal homeostasis: the androgen-resistant testicular feminized male mouse model. Journal of Bone and Mineral Research. ,vol. 19, pp. 1462- 1470 ,(2004) , 10.1359/JBMR.040505
Patricia Ducy, Rui Zhang, Valérie Geoffroy, Amy L Ridall, Gérard Karsenty, Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation Cell. ,vol. 89, pp. 747- 754 ,(1997) , 10.1016/S0092-8674(00)80257-3
Sunil Srivastava, Gianluca Toraldo, M. Neale Weitzmann, Simone Cenci, F. Patrick Ross, Roberto Pacifici, Estrogen Decreases Osteoclast Formation by Down-regulating Receptor Activator of NF-κB Ligand (RANKL)-induced JNK Activation Journal of Biological Chemistry. ,vol. 276, pp. 8836- 8840 ,(2001) , 10.1074/JBC.M010764200
T Komori, H Yagi, S Nomura, A Yamaguchi, K Sasaki, K Deguchi, Y Shimizu, R.T Bronson, Y.-H Gao, M Inada, M Sato, R Okamoto, Y Kitamura, S Yoshiki, T Kishimoto, Targeted Disruption of Cbfa1 Results in a Complete Lack of Bone Formation owing to Maturational Arrest of Osteoblasts Cell. ,vol. 89, pp. 755- 764 ,(1997) , 10.1016/S0092-8674(00)80258-5