Risk of re-identification of epigenetic methylation data: a more nuanced response is needed.
作者： Yann Joly , Stephanie OM Dyke , Warren A Cheung , Mark A Rothstein , Tomi Pastinen
DOI: 10.1186/S13148-015-0079-Z
关键词: Data sharing 、 Human genetics 、 Computational biology 、 Epigenome 、 Epigenetics 、 Re identification 、 Protected health information 、 Bioinformatics 、 Methylation 、 Psychology 、 Letter to the editor
摘要: In this letter to the editor, we respond recent publication by Philibert et al. Methylation array data can simultaneously identify individuals and convey protected health information: an unrecognized ethical concern (Clinical Epigenetics 2014, 6:28). Further discussion of issues raised risk re-identification epigenetic methylation is needed, a more nuanced approach should be taken with respect its implications for sharing policy than one provided.
biomedcentral.com
springer.com
paperity.org
core.ac.uk 参考文章(10)
Yi-an Chen, Mathieu Lemire, Sanaa Choufani, Darci T. Butcher, Daria Grafodatskaya, Brent W. Zanke, Steven Gallinger, Thomas J. Hudson, Rosanna Weksberg, Discovery of cross-reactive probes and polymorphic CpGs in the Illumina Infinium HumanMethylation450 microarray Epigenetics. ,vol. 8, pp. 203- 209 ,(2013) , 10.4161/EPI.23470
Yaniv Erlich, Arvind Narayanan, Routes for breaching and protecting genetic privacy Nature Reviews Genetics. ,vol. 15, pp. 409- 421 ,(2014) , 10.1038/NRG3723
Carol J. Weil, Leah E. Mechanic, Tiffany Green, Christopher Kinsinger, Nicole C. Lockhart, Stefanie A. Nelson, Laura L. Rodriguez, Laura D. Buccini, NCI think tank concerning the identifiability of biospecimens and “omic” data Genetics in Medicine. ,vol. 15, pp. 997- 1003 ,(2013) , 10.1038/GIM.2013.40
Djims Milius, Edward S Dove, Donald Chalmers, Stephanie O M Dyke, Kazuto Kato, Pilar Nicolás, BF Francis Ouellette, Brad Ozenberger, Laura L Rodriguez, Nikolajs Zeps, Yann Joly, The International Cancer Genome Consortium's evolving data-protection policies. Nature Biotechnology. ,vol. 32, pp. 519- 523 ,(2014) , 10.1038/NBT.2926
Nils Homer, Szabolcs Szelinger, Margot Redman, David Duggan, Waibhav Tembe, Jill Muehling, John V Pearson, Dietrich A Stephan, Stanley F Nelson, David W Craig, None, Resolving individuals contributing trace amounts of DNA to highly complex mixtures using high-density SNP genotyping microarrays. PLOS Genetics. ,vol. 4, ,(2008) , 10.1371/JOURNAL.PGEN.1000167
Eric E Schadt, Sangsoon Woo, Ke Hao, Bayesian method to predict individual SNP genotypes from gene expression data Nature Genetics. ,vol. 44, pp. 603- 608 ,(2012) , 10.1038/NG.2248
Magda E Price, Allison M Cotton, Lucia L Lam, Pau Farré, Eldon Emberly, Carolyn J Brown, Wendy P Robinson, Michael S Kobor, Additional annotation enhances potential for biologically-relevant analysis of the Illumina Infinium HumanMethylation450 BeadChip array Epigenetics & Chromatin. ,vol. 6, pp. 4- 4 ,(2013) , 10.1186/1756-8935-6-4
Anand Sarwate, Sergey Plis, Jessica Turner, Vince Arbabshirani, Mohammad, Calhoun, Sharing privacy-sensitive access to neuroimaging and genetics data: a review and preliminary validation Frontiers in Neuroinformatics. ,vol. 8, pp. 35- 35 ,(2014) , 10.3389/FNINF.2014.00035
Robert A Philibert, Nicolas Terry, Cheryl Erwin, Winter J Philibert, Steven RH Beach, Gene H Brody, Methylation array data can simultaneously identify individuals and convey protected health information: an unrecognized ethical concern Clinical Epigenetics. ,vol. 6, pp. 28- 28 ,(2014) , 10.1186/1868-7083-6-28
Florence Guida, Torkjel M. Sandanger, Raphaële Castagné, Gianluca Campanella, Silvia Polidoro, Domenico Palli, Vittorio Krogh, Rosario Tumino, Carlotta Sacerdote, Salvatore Panico, Gianluca Severi, Soterios A. Kyrtopoulos, Panagiotis Georgiadis, Roel C.H. Vermeulen, Eiliv Lund, Paolo Vineis, Marc Chadeau-Hyam, Dynamics of smoking-induced genome-wide methylation changes with time since smoking cessation Human Molecular Genetics. ,vol. 24, pp. 2349- 2359 ,(2015) , 10.1093/HMG/DDU751