Fluctuations of Histone Chemical Modifications in Breast, Prostate, and Colorectal Cancer: An Implication of Phytochemicals as Defenders of Chromatin Equilibrium
作者： Marek Samec , Alena Liskova , Lenka Koklesova , Veronika Mestanova , Maria Franekova
DOI: 10.3390/BIOM9120829
关键词: Colorectal cancer 、 Carcinogenesis 、 Prostate cancer 、 Acetylation 、 Epigenome 、 Cancer research 、 Biology 、 Chromatin 、 Histone 、 Epigenetics
摘要: Natural substances of plant origin exert health beneficiary efficacy due to the content various phytochemicals. Significant anticancer abilities natural compounds are mediated via processes such as regulation a cell’s epigenome. The potential antineoplastic activity by their action on posttranslational histone modifications (PHMs) is currently highly evaluated area cancer research. PHMs play an important role in maintaining chromatin structure and regulating gene expression. Aberrations directly linked process carcinogenesis breast (BC), prostate (PC), colorectal (CRC) cancer, common malignant diseases terms incidence mortality among both men women. This review summarizes effects phytochemicals (isolated or mixtures) cancer-associated (mainly modulation acetylation methylation) resulting alterations that related transcription specific oncogenes, which crucial development BC, PC, CRC. effectiveness aberrant were confirmed number vitro vivo studies preclinical However, evidence concerning PHMs-modulating plant-based clinical trials insufficient.
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