Severity of presentation is associated with time to recovery in spinal epidural lipomatosis

作者: Moshe Praver , Benjamin C. Kennedy , Jason A. Ellis , Randy D’Amico , Christopher E. Mandigo

DOI: 10.1016/J.JOCN.2015.03.005

关键词: MedicineExact testAnesthesiaEpidural spaceCumulative doseAnalysis of varianceSurgeryPrednisoneRare diseaseLipomatosisStatistical significance

摘要: We present a patient with prednisone-induced spinal epidural lipomatosis (SEL) and relatively acute neurologic deterioration followed by rapid recovery after surgical decompression. SEL is rare disease characterized hypertrophy of fat, most commonly associated exogenous steroid use. To our knowledge, an analysis the dynamics dose related to time onset has never been performed, or presentation features respect outcome. retrospectively reviewed literature for English language series case reports prednisone use from 1975–2013. Data were compiled 41 patients regarding prescribed length treatment, as well severity symptoms on Ranawat scale, onset, recovery, degree neurological symptoms. Fisher’s exact test variance used comparing proportions, p values <0.05 considered statistically significant. found that mean cumulative trended towards association lack (p = 0.06) may be rate recovery. Prescribed varied inversely before symptoms, but failed reach statistical significance. Higher presenting scale higher likelihood delayed 0.035). Patients lower more frequently experienced complete though this did not The acuity was ultimate Severity in patients. Cumulative Acuity

参考文章(47)
C S Ranawat, P OʼLeary, P Pellicci, P Tsairis, P Marchisello, L Dorr, Cervical spine fusion in rheumatoid arthritis. The Journal of Bone & Joint Surgery. ,vol. 61, pp. 1003- 1010 ,(1979) , 10.2106/00004623-197961070-00006
Richard J. Bransford, Jens R. Chapman, Andrea C. Skelly, Ellen M. VanAlstyne, What do we currently know about thoracic spinal cord injury recovery and outcomes? A systematic review. Journal of Neurosurgery. ,vol. 17, pp. 52- 64 ,(2012) , 10.3171/2012.6.AOSPINE1287
Christian A Koch, John L Doppman, Nicholas J Patronas, Lynnette K Nieman, George P Chrousos, Do Glucocorticoids Cause Spinal Epidural Lipomatosis? When Endocrinology and Spinal Surgery Meet Trends in Endocrinology & Metabolism. ,vol. 11, pp. 86- 90 ,(2000) , 10.1016/S1043-2760(00)00236-8
Scott C. Robertson, Vincent C. Traynelis, Kenneth A. Follett, Arnold H. Menezes, Idiopathic spinal epidural lipomatosis. Neurosurgery. ,vol. 41, pp. 68- 75 ,(1997) , 10.1097/00006123-199707000-00015
B. Fiirgaard, F. H. Madsen, Spinal epidural lipomatosis. Case report and review of the literature Scandinavian Journal of Medicine & Science in Sports. ,vol. 7, pp. 354- 357 ,(2007) , 10.1111/J.1600-0838.1997.TB00166.X
D. Buthiau, J. C. Piette, M. N. Ducerveau, G. Robert, P. Godeau, F. Heitz, Steroid-induced spinal epidural lipomatosis: CT survey Journal of Computer Assisted Tomography. ,vol. 12, pp. 501- 503 ,(1988) , 10.1097/00004728-198805010-00030
Daniel G. Borré, Guillermo E. Borré, Flavio Aude, Gladys N. Palmieri, Lumbosacral epidural lipomatosis: MRI grading European Radiology. ,vol. 13, pp. 1709- 1721 ,(2003) , 10.1007/S00330-002-1716-4
H.-J. Andress, Mathias Schürmann, Andreas Heuck, Jochen Schmand, Günter Lob, A rare case of osteoporotic spine fracture associated with epidural lipomatosis causing paraplegia following long-term cortisone therapy. Archives of Orthopaedic and Trauma Surgery. ,vol. 120, pp. 484- 486 ,(2000) , 10.1007/S004029900086
Mark E. Healy, John R. Hesselink, Richard C. Ostrup, John F. Alksne, Demonstration by magnetic resonance of symptomatic spinal epidural lipomatosis. Neurosurgery. ,vol. 21, pp. 414- 415 ,(1987) , 10.1227/00006123-198709000-00026