作者: Moshe Praver , Benjamin C. Kennedy , Jason A. Ellis , Randy D’Amico , Christopher E. Mandigo
DOI: 10.1016/J.JOCN.2015.03.005
关键词: Medicine 、 Exact test 、 Anesthesia 、 Epidural space 、 Cumulative dose 、 Analysis of variance 、 Surgery 、 Prednisone 、 Rare disease 、 Lipomatosis 、 Statistical significance
摘要: We present a patient with prednisone-induced spinal epidural lipomatosis (SEL) and relatively acute neurologic deterioration followed by rapid recovery after surgical decompression. SEL is rare disease characterized hypertrophy of fat, most commonly associated exogenous steroid use. To our knowledge, an analysis the dynamics dose related to time onset has never been performed, or presentation features respect outcome. retrospectively reviewed literature for English language series case reports prednisone use from 1975–2013. Data were compiled 41 patients regarding prescribed length treatment, as well severity symptoms on Ranawat scale, onset, recovery, degree neurological symptoms. Fisher’s exact test variance used comparing proportions, p values <0.05 considered statistically significant. found that mean cumulative trended towards association lack (p = 0.06) may be rate recovery. Prescribed varied inversely before symptoms, but failed reach statistical significance. Higher presenting scale higher likelihood delayed 0.035). Patients lower more frequently experienced complete though this did not The acuity was ultimate Severity in patients. Cumulative Acuity