Increased brain NAD prevents neuronal apoptosis in vivo.
作者： Suman K Mukherjee , Lori K Klaidman , Ramona Yasharel , James D Adams
DOI: 10.1016/S0014-2999(97)00171-4
关键词: MPTP 、 NAD+ kinase 、 Neurotoxin 、 Cell biology 、 Nicotinamide 、 Substantia nigra 、 Biochemistry 、 Neurodegeneration 、 Programmed cell death 、 Biology 、 Xanthine oxidase
摘要: Apoptosis is a characteristic form of cell death which has been implicated in neurodegeneration. In this study we document the induction apoptosis and DNA fragmentation vivo by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), neurotoxin. MPTP selectively damages dopaminergic neurons substantia nigra midbrain. It potent inducer oxygen radicals. Nicotinamide, precursor NAD, able to block induced MPTP. Nicotinamide also quenches some radicals formed xanthine oxidase. may be interest treatment
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