A discrepancy between the effects of a single oral dose of captopril on blood pressure, plasma renin activity, and serum angiotensin-converting enzyme levels.

摘要: The effects of a single oral dose (100 mg) the angiotensin-converting enzyme (ACE) inhibitor, captopril (SQ 14,224), on blood pressure (BP), plasma renin activity (PRA), aldosterone (PA), and serum ACE were investigated in 18 patients with essential hypertension (EH) 4 renovascular (RVH). most patients, SQ 14,225 caused significant reduction BP during subsequent 6 h, particularly RVH patients. A correlation between basal PRA levels was observed only by considering all together. After blockade, increase normal-renin EH but not lower PRA. Maximal inhibition (over 50%) occurred after 2 h diminished whereas decrease persisted for h. 3-day treatment indomethacin (six patients) captopril's antihypertensive action blunted, despite baseline captopril-induced elevation. low-renin lack effect blockade secretion these refute interpretation purely angiotensin-related mechanism.